Clinical Monitoring of an Alcohol Hangover Support

Indigenous Herb on Alcohol Toxicity Relative to Hangovers

A total of 5 persons (4 males and 1 female) were monitored for their baseline blood alcohol levels using a Lifeloc Portable Breath Tester which was designed for Law Enforcement and Corrections use. The Lifeloc unit is tested and approved by the US. Department of Transportation/NHTSA and used multiple state forensic laboratories. They were given both clear and dark liquors to the point of intoxication. *NOTE all subjects departed the clinical trial totally sober and more importantly none suffered the effects of hangover.

General Information on Alcohol Metabolism

When alcohol is consumed, it passes from the stomach and intestines into the blood, a process referred to as absorption. Alcohol is then metabolized by enzymes, which are body chemicals that break down other chemicals. Alcohol is metabolized in the liver by the enzyme cytochrome P450IIE1 (CYP2E1), which may be increased after chronic drinking. Most of the alcohol consumed is metabolized in the liver, but the small quantity that remains un-metabolized permits alcohol concentration to be measured in breath and urine.

The liver can metabolize only a certain amount of alcohol per hour, regardless of the amount that has been consumed. In general, after the consumption of one standard drink, the amount of alcohol in the drinker's blood (blood alcohol concentration, or BAC) peaks within 30 to 45 minutes. (A standard drink is defined as 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of 80-proof distilled spirits, all of which contain the same amount of alcohol.) The BAC curve, shown on the next page, provides an estimate of the time needed to absorb and metabolize different amounts of alcohol.

Hangover Data

Scientific data reveals that 1.5 g/kg of alcohol (approximately 5 to 6 drinks for a 166 lb man and 3 to 5 drinks for a 132 lb woman) will almost always lead to hangover. Alcohol hangover is characterized by headache, tremulousness, nausea, diarrhea, and fatigue combined with decreased occupational, cognitive, or visual-spatial skill performance. In the United States, related absenteeism and poor job performance cost $148 billion annually (average annual cost per working adult, $2000).

Most of us believe that the person most likely associated with a hangover is an alcoholic, yet most of the cost of hangovers is incurred by the light-to-moderate drinker. Patients with hangover may pose substantial risk to themselves and others despite having a normal blood alcohol level. Hangover may also be an independent risk factor for cardiac death.

Although hangover may be interpreted as merely uncomfortable, the patient with hangover is at increased risk for injury and poor job performance. Patients with hangover have diminished visual-spatial skills and dexterity, even after alcohol can no longer be detected in the blood. One study of 178 persons found that "those who experience greater hangover may choose to drink more alcohol in order to relieve these adverse effects." Therefore, successful treatment of hangover could mitigate total alcohol consumption.

N.H.I.L. Short Clinical Trial .- Five adult subjects were checked for baseline blood alcohol levels and then give either, vodka, tequila and rum or a mixture of each. The individuals were given hard liquor from 4-8 drinks consisting of 1.5 oz of alcohol. Please refer to the above table which indicates that 4 drinks will take approximately 7 hours for the body to detoxify the alcohol.

After receiving 4-6 drinks in rapid succession the subjects were given ALCOHOL HANGOVER SUPPORT; two (2oz.) servings were drunk after the person reached the state of being legally impaired by alcohol to the point they would have been arrested had they been on the road. All of these subjects per the scientific data listed above would have had a hangover.

ALCOHOL HANGOVER SUPPORT appears to help the liver detoxify via the cytochrome P-450 pathways helping to metabolize alcohol approximately 2 times faster than the body would do on its own. Alcohol is a neurotoxin usually combined with more toxins from the distillation process to include sugars, dyes, and other chemicals. It is no wonder that we wake up with a HANGOVER.  We are literally soaked with toxins that the liver can't detoxify fast enough. These toxins affect our blood sugar levels, impair hormone function, dehydrate us and cause neural impairment. ALCOHOL HANGOVER SUPPORT was very effective in helping the Phase I & Phase II Liver Detoxification Pathways break down the neurotoxin alcohol and the accompanying distillation impurities approximately 2 times faster, and all subjects reported no hangover symptoms to include nausea, upset stomach, dizziness, and headache or washed out feeling.