Formula Design for Subjects with Benign Prostatic Hyperplasia
Male over 50 are statistically prone to suffer from a prostate gland disorder, and if not the odds are 2 to 1 that this disorder will set before the age of 60. By the age of 65, most American men have enlarged prostates. As the years pass, mild discomforts can become disabling. Today, prostate surgery is the second most commonly performed surgery for non-cancerous benign prostatic hyperplasia (BPH) in men over age 65.
Given the inherent possible surgical complications that can result, prescription drugs frequently are the first alternative of choice by most practitioners. Prescription drugs may halt the swelling, but many of these drugs may also have side effects.
Many doctors feel that disorders of BPH can be treated or prevented by giving the prostate gland the nutrition it lacks. Recent scientific research has shown how to remedy the underlying problems associated with disorders of BPH -- safely and effectively. The use of herbal combinations for BPH have been scientifically studied and have been shown to not only be effective and safe, they produce little or no side effects.
If you are experiencing one or more than one of the following symptoms, you may be suffering from an enlarged prostate:
- Frequent or sudden need to urinate
- Nocturia (Having to urinate frequently at night)
- Weak urine flow
- Need to strain or push bladder to urinate
- Difficulty beginning urination especially at night
- Feeling that your bladder never completely empties
- Pain or burning during urination
In order to address all the major symptoms of BPH and bring fast relief, N.H.I.L. designed a formula in a unique proprietary blend of four highly effective herbal remedies combined with other natural ingredients in therapeutic dosage. The following formula is also designed to help prevent recurrent episodes of BPH and prostate problems. N.H.I.L.'s formula is a safe formulated compound of proven natural ingredients for treating BPH.
ACTIVE INGREDIENTS:
Saw Palmetto (Serenoa repens): This herb has been shown in numerous clinical studies to improve greatly the signs and symptoms of an enlarged prostate known as benign prostatic hyperplasia (BPH). This effect is due to Saw palmetto's ability to inhibit the formation of dihydrotestosterone, the compound which seem to cause the prostate cells to multiple excessively. Saw palmetto inhibits dihydrotestosterone at its initial synthesis, as well as at cellular binding sites, thereby greatly antagonizing the effects of this compound on the prostate. Saw palmetto is an herb that has been shown in clinical studies to have an important role in maintaining a healthy prostate. Saw palmetto grows naturally in the southeast United States particularly in Florida.
Saw palmetto is a standard medical treatment for BPH utilized by many countries throughout Europe. The fat soluble extract of saw palmetto berry when used regularly reduces and keeps symptoms in check. Research suggests that the fat soluble constituents found in saw palmetto berry inhibits an enzyme 5-alpha reductase which in turn converts testosterone to its more active form dihydrotestosterone (DHT) which in turn binds to prostatic tissue. Interestingly this form of testosterone has also been implicated in male pattern baldness
Pumpkin Seed: This ingredient is added to the formula to enhance diuretic activity. Studies have shown that pumpkin seeds act as a non-irritating diuretic. This property makes the seed extract especially well suited to treat an enlarged prostate. Two studies have indicated that pumpkin seed oil and Saw palmetto effectively reduced the symptoms of BPH.
Pygeum africanum: Double-blind clinical trials have shown efficacy for many parameters of prostatic hypertrophy, including failure to urinate, nocturnal urination, frequent urination, residual urine, abdominal heaviness, voiding volume, prostate volume and peak flow. Results included significant reduction of symptoms and prostate size, and clearance of bladder neck urethra obstruction. The active constituents of Pygeum extract include phytosterols that have anti-inflammatory effects by inhibiting production of pro-inflammatory prostaglandins in the prostate.
Stinging Nettle (Urtica dioica): Extracts from the roots of the stinging nettle are used in the treatment of benign prostatic hyperplasia. The mechanisms underlying this treatment have not been explained. Researchers have set out to determine whether specific extracts from the stinging nettle plant had the ability to change the receptor sites on the prostate that receive specific hormone proteins. Four substances contained in stinging nettle were examined. Of these, only the aqueous extract was active. It stopped the binding of the hormone protein to its receptor sites. This is a possible explanation for the effectiveness of stinging nettle on prostatis ((infections and inflammation)). The inhibition was dose related, starting at about 0.6 mg/ml and completely inhibited binding at 10 mg/ml. The effect of extracts of the roots of the stinging nettle is on the interaction of SHBG (Sex Hormone Binding Globulin) with its receptor on human prostatic membranes.
Beta Sitosterol: The best and most convincing study of the efficacy of a phyto-therapeutic agent was published in Lancet in 1995 using this compound. This study was double-blind, placebo controlled and matched in design and format with pharmaceutical industry trials for alpha blockers and hormones. They used pure beta-sitosterol with 200 men half of whom received a placebo over the course of a year. They said, "Significant improvement in symptoms and urinary flow parameters show the effectiveness of beta-sitosterol in the treatment of BPH." This is clearly one of the most important and well done studies on prostate ever published.
References:
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12. Tasca, A., Barulli, M., Cavazzana, A., et al., "Treatment of obstructive symptomatology caused by prostatic adenoma with an extract of Serenoa repens. Double-blind clinical study vs. placebo", Minerva Urol. Nefrol., 1985, 37, pp. 87-91
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